Midfield
The central midfield is likely to be marshalled by Mark Noble and Pedro Obiang. Both of these players will be crucial in the clash against the Latics and a lot will depend on their performance. They have to shield the backline, push the side forward and dictate the tempo of the game from the middle.
The responsibility of the no.10 position is likely to be shouldered by Josh Cullen. The youngster started in both the fixtures against Shrewsbury Town and could possibly get his third start in the FA Cup this season.
Attack
We expect Javier Hernandez to lead the line against Wigan. Hernandez found the back of the net against Bournemouth on Saturday in the Premier League fixture and Moyes is expected to hand the Mexican his second start in as many games.
On the right-wing, we might see Andre Ayew making a return to showcase his attacking prowess whereas at the left-wing, we expect Sead Haksabanovic to play in the absence of Lanzini.